SIGLEC10

Across TCGA cell cohorts, SIGLEC10 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,611 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SIGLEC10-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cellular anatomical structure, Symbiont-mediated disruption of host anatomical structure, and Negative regulation of gene expression, epigenetic. Each is linked with SIGLEC10 in more than 8 cancer types. Because this analysis shows association rather than direction, both SIGLEC10-to-partner and partner-to-SIGLEC10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Symbiont-mediated disruption of host cellular anatomical structure grouped by SIGLEC10-low versus SIGLEC10-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC10→partner) and Y-score (partner→SIGLEC10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Symbiont-mediated disruption of host cellular anatomical structure →	+0.099	+2.169	<.001	<.001	3	9
BLOOD_Lymphoma	Symbiont-mediated disruption of host anatomical structure →	+0.099	+2.169	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of gene expression, epigenetic →	+0.055	+0.142	.003	.006	3	8
PANCREAS	Regulation of sphingolipid biosynthetic process →	+0.052	+0.125	.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of double-strand break repair →	+0.069	+0.162	.001	.002	3	7
BLOOD_Lymphoma	Positive regulation of DNA repair →	+0.058	+2.643	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,611 associations by consensus.

Symbiont-mediated disruption of host cellular anatomical structure by SIGLEC10 expression — BLOOD_Lymphoma

Explore this box plot interactively →