SIGLEC10-AS1

Across TCGA pan-cancer cohorts, SIGLEC10-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SIGLEC10-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SIGLEC10-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SIGLEC10-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.

KIRC, ACC, and UCS are the cancer types where SIGLEC10-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.521	0.687	<.001	112	view →
ACC	OS	Quartile	All	0.306	0.714	<.001	75	view →
UCS	OS	Median	II,III,IV	0.583	0.222	.004	58	view →
LGG	DFS	Median	All	0.630	0.842	<.001	54	view →
UCEC	OS	Quartile	All	0.826	0.914	.006	40	view →
READ	OS	Median	All	0.975	0.848	.001	24	view →
PRAD	DFS	Tertile	All	0.663	0.821	<.001	20	view →
SKCM	OS	Median	II,III,IV	0.492	0.291	.004	19	view →
LUAD	DFS	Quartile	IV	0.412	0.912	.004	18	view →
DLBC	DFS	Median	All	0.579	1.000	.007	17	view →
PAAD	OS	Tertile	All	0.234	0.478	.017	15	view →
MESO	DFS	Tertile	IV	0.211	0.531	.011	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SIGLEC10-AS1–KIRC (DFS)

Open the KIRC breakdown →