SIGLEC1

Across TCGA patient cohorts, SIGLEC1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,429 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SIGLEC1-associated genes across cancer lineages are FCER1G, MEFV, and LILRB1. Each is linked with SIGLEC1 in more than 9 cancer types. Because this analysis shows association rather than direction, both SIGLEC1-to-partner and partner-to-SIGLEC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIGLEC1 versus FCER1G in UCEC, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC1→partner) and Y-score (partner→SIGLEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FCER1G →	+1.003	+0.527	<.001	.003	3	10
LSCC	MEFV →	+0.791	+0.487	<.001	<.001	3	9
UCEC	LILRB1 →	+1.079	+0.701	.003	<.001	3	9
BRCA	OAS2 →	+1.472	+0.443	<.001	<.001	3	9
UCEC	LILRB2 →	+0.983	+0.779	.002	<.001	3	9
GBM	IFI44L →	+1.849	+0.805	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,429 associations by consensus.

SIGLEC1 vs FCER1G — UCEC

Explore this scatter interactively →