SIGLEC1

Across TCGA patient cohorts, SIGLEC1 mutation is significantly associated with the RNA expression of many other genes, with 4,881 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIGLEC1-associated genes across cancer lineages are LINC02326, MIR3661, and SKA1. Each is linked with SIGLEC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SIGLEC1-to-partner and partner-to-SIGLEC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02326 grouped by SIGLEC1-low versus SIGLEC1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC1→partner) and Y-score (partner→SIGLEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	LINC02326 →	+0.027	+4.095	<.001	.007	3	4
SKCM	MIR3661 →	+0.093	+1.552	.001	.002	3	4
UCEC	SKA1 →	+0.720	+2.332	<.001	<.001	3	4
UCEC	DONSON →	+0.441	+1.657	<.001	<.001	3	4
LUSC	HDGFL2 →	+0.337	+1.784	.007	.004	3	4
UCEC	PBK →	+0.787	+1.977	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,881 associations by consensus.

LINC02326 by SIGLEC1 expression — LIHC

Explore this box plot interactively →