SIGLEC1

Across TCGA patient cohorts, SIGLEC1 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIGLEC1-associated genes across cancer lineages are Caspase-7-cleavedD198, PDCD4, and PKC-b-II_pS660. Each is linked with SIGLEC1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SIGLEC1-to-partner and partner-to-SIGLEC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SIGLEC1-low versus SIGLEC1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC1→partner) and Y-score (partner→SIGLEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.215	+3.593	<.001	.001	3	6
UCEC	PDCD4 →	-0.566	-1.765	<.001	<.001	3	4
COAD	PKC-b-II_pS660 →	-0.393	-2.450	.010	.020	3	3
UCEC	4E-BP1 →	+0.356	+2.459	<.001	<.001	3	3
UCEC	FOXO3a_pS318_S321 →	-0.103	-1.744	.002	<.001	3	3
UCEC	GAPDH →	+0.315	+1.247	.031	.038	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

Caspase-7-cleavedD198 by SIGLEC1 expression — COAD

Explore this box plot interactively →