SIGLEC1

Across TCGA cell cohorts, SIGLEC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 672 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible SIGLEC1-associated GO terms across cancer lineages are Intraciliary retrograde transport, Photoreceptor cell maintenance, and Reticulophagy. Each is linked with SIGLEC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SIGLEC1-to-partner and partner-to-SIGLEC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intraciliary retrograde transport grouped by SIGLEC1-low versus SIGLEC1-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC1→partner) and Y-score (partner→SIGLEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Intraciliary retrograde transport →	+0.064	+0.018	.001	.005	3	5
SKIN	Photoreceptor cell maintenance →	+0.047	+0.010	.003	<.001	3	4
PANCREAS	Reticulophagy →	+0.087	+0.019	<.001	.006	3	4
KIDNEY	Negative regulation of ion transmembrane transporter activity →	-0.156	-0.021	<.001	<.001	3	4
SOFT_TISSUE	Peptidyl-amino acid modification →	+0.029	+0.043	<.001	.003	3	4
OESOPHAGUS	Regulation of synaptic membrane adhesion →	+1.163	+0.035	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 672 associations by consensus.

Intraciliary retrograde transport by SIGLEC1 expression — LUNG_NSCLC_LUAD

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