SIGLEC1

Across TCGA cell cohorts, SIGLEC1 mutation is significantly associated with the RNA expression of many other genes, with 1,291 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIGLEC1-associated genes across cancer lineages are CCL16, MREG, and CSH1. Each is linked with SIGLEC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIGLEC1-to-partner and partner-to-SIGLEC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL16 grouped by SIGLEC1-low versus SIGLEC1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC1→partner) and Y-score (partner→SIGLEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CCL16 →	+0.030	+4.807	<.001	.006	3	3
LUNG_NSCLC_LUAD	MREG →	+0.840	+3.621	<.001	<.001	3	2
LUNG_NSCLC_LUAD	CSH1 →	+0.028	+2.121	<.001	.005	3	2
LUNG_NSCLC_LUAD	IFNLR1 →	+0.813	+2.495	.003	.006	3	2
LUNG_NSCLC_LUAD	SLC15A5 →	+0.005	+1.983	.003	.007	3	2
LUNG_NSCLC_LUAD	NOL4L →	-0.821	-3.265	.006	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,291 associations by consensus.

CCL16 by SIGLEC1 expression — BLOOD_Myeloma

Explore this box plot interactively →