Across TCGA pan-cancer cohorts, SIGIRR Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SIGIRR data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in prostate adenocarcinoma (PRAD), where higher SIGIRR Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SIGIRR expression acts as an unfavorable survival marker.

PRAD and UCEC are the cancer types where SIGIRR Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SIGIRR tumor-vs-normal RNA expression · all SIGIRR data types