Across TCGA pan-cancer cohorts, SIGIRR mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SIGIRR data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SIGIRR mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SIGIRR expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where SIGIRR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.889	0.627	.002	34	view →
LUAD	DFS	Tertile	All	0.846	0.997	.012	10	view →
HNSC	DFS	Quartile	All	0.763	0.513	.035	3	view →
LSCC	OS	Tertile	All	0.727	0.906	.027	3	view →
UCEC	OS	Quartile	All	1.000	0.882	.022	2	view →
PDAC	DFS	Quartile	II,III,IV	0.600	0.328	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: SIGIRR tumor-vs-normal RNA expression · all SIGIRR data types