SIDT2

Across TCGA patient cohorts, SIDT2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIDT2-associated genes across cancer lineages are p62 Lck ligand, PCNA, and PDCD4. Each is linked with SIDT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIDT2-to-partner and partner-to-SIDT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by SIDT2-low versus SIDT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIDT2→partner) and Y-score (partner→SIDT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.390	+2.201	<.001	<.001	3	2
UCEC	PCNA →	+0.169	+1.584	.019	.009	3	2
UCEC	PDCD4 →	-0.424	-2.700	.007	.005	3	2
UCEC	Annexin-1 →	+0.469	+2.242	.007	.005	3	2
UCEC	ATM →	-0.514	-1.584	<.001	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.826	+2.604	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

p62 Lck ligand by SIDT2 expression — UCEC

Explore this box plot interactively →