SIDT2

Across TCGA cell cohorts, SIDT2 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SIDT2-associated genes across cancer lineages are CBLIF, PRSS58, and CRYGA. Each is linked with SIDT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIDT2-to-partner and partner-to-SIDT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBLIF grouped by SIDT2-low versus SIDT2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIDT2→partner) and Y-score (partner→SIDT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBLIF →	+0.257	+3.478	.003	.002	3	2
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	1
BLOOD_Leukemia	CRYGA →	+0.019	+3.969	<.001	.009	3	1
BLOOD_Leukemia	KRTAP2-1 →	+0.047	+3.969	<.001	.009	3	1
OVARY	OR6T1 →	+0.016	+5.196	<.001	.005	3	1
OVARY	IQCF2 →	+0.052	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

CBLIF by SIDT2 expression — LARGE_INTESTINE

Explore this box plot interactively →