SIAH2

Across TCGA patient cohorts, SIAH2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,695 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SIAH2-associated genes across cancer lineages are STC2, TMEM150B, and CIPC. Each is linked with SIAH2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIAH2-to-partner and partner-to-SIAH2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIAH2 versus STC2 in BRCA, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIAH2→partner) and Y-score (partner→SIAH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	STC2 →	+2.166	+0.626	<.001	<.001	3	3
UCEC	TMEM150B →	-1.199	-0.579	.001	.002	3	3
UCEC	CIPC →	+0.748	+0.772	.001	<.001	3	3
UCEC	ARRDC5 →	-0.735	-0.470	.002	.005	3	3
BRCA	SLC52A3 →	+0.785	+0.493	.005	.003	3	3
CCRCC	CRISPLD2 →	-0.966	-0.644	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,695 associations by consensus.

SIAH2 vs STC2 — BRCA

Explore this scatter interactively →