SIAH2

Across TCGA patient cohorts, SIAH2 mutation is significantly associated with the RNA expression of many other genes, with 1,349 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIAH2-associated genes across cancer lineages are SDR42E1P4, RNU6-904P, and RNU6-463P. Each is linked with SIAH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIAH2-to-partner and partner-to-SIAH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SDR42E1P4 grouped by SIAH2-low versus SIAH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIAH2→partner) and Y-score (partner→SIAH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SDR42E1P4 →	+0.036	+4.978	<.001	.001	3	2
LUAD	RNU6-904P →	+0.248	+6.333	<.001	<.001	3	2
HNSC	RNU6-463P →	+0.363	+7.954	<.001	.008	3	1
BLCA	ULK4P1 →	+0.044	+4.238	.006	.008	3	1
UCEC	AQP7P3 →	+0.036	+3.675	<.001	<.001	3	1
UCEC	LINC01943 →	+0.742	+2.447	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,349 associations by consensus.

SDR42E1P4 by SIAH2 expression — UCEC

Explore this box plot interactively →