SIAH2

Across TCGA cell cohorts, SIAH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,352 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SIAH2-associated GO terms across cancer lineages are Regulation of post-translational protein modification, Amyloid fibril formation, and Regulation of cap-independent translational initiation. Each is linked with SIAH2 in more than 8 cancer types. Because this analysis shows association rather than direction, both SIAH2-to-partner and partner-to-SIAH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of post-translational protein modification grouped by SIAH2-low versus SIAH2-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIAH2→partner) and Y-score (partner→SIAH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of post-translational protein modification →	+0.063	+0.932	.001	<.001	3	9
LUNG_SCLC	Amyloid fibril formation →	+0.129	+1.136	<.001	.001	3	9
OESOPHAGUS	Regulation of cap-independent translational initiation →	+0.120	+0.610	<.001	.004	3	8
OESOPHAGUS	Positive regulation of cap-independent translational initiation →	+0.120	+0.610	<.001	.004	3	8
OVARY	Positive regulation of cytoplasmic translation →	+0.122	+0.752	.002	.002	3	8
OESOPHAGUS	Regulation of cap-dependent translational initiation →	+0.149	+0.647	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,352 associations by consensus.

Regulation of post-translational protein modification by SIAH2 expression — OVARY

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