SIAH2-AS1

Across TCGA pan-cancer cohorts, SIAH2-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SIAH2-AS1 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SIAH2-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SIAH2-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and KIRC show a favorable association.

BRCA, KIRC, and UCS are the cancer types where SIAH2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.954	0.894	<.001	126	view →
KIRC	OS	Tertile	All	0.726	0.534	<.001	87	view →
UCS	DFS	Quartile	All	0.705	0.179	<.001	84	view →
UVM	OS	Tertile	II,III,IV	0.803	0.459	.006	53	view →
LUSC	DFS	Median	All	0.802	0.691	.001	48	view →
ACC	OS	Median	IV	0.842	0.244	.001	22	view →
COAD	DFS	Tertile	III,IV	0.473	0.740	.008	20	view →
LUAD	OS	Median	All	0.452	0.264	<.001	19	view →
STAD	OS	Tertile	III,IV	0.868	0.359	.001	18	view →
THCA	DFS	Median	II,III,IV	0.765	0.958	.003	13	view →
KIRP	OS	Median	III,IV	0.899	0.679	.014	13	view →
LIHC	OS	Tertile	III,IV	0.709	0.371	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SIAH2-AS1–BRCA (OS)

Open the BRCA breakdown →