Across TCGA pan-cancer cohorts, SIAH1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SIAH1 data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher SIAH1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SIAH1 expression acts as an unfavorable survival marker.

UCS and LIHC are the cancer types where SIAH1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	All	0.136	0.523	.034	6	view →
LIHC	DFS	Median	III,IV	0.081	0.413	.048	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SIAH1 tumor-vs-normal RNA expression · all SIAH1 data types