Across TCGA pan-cancer cohorts, SIAH1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SIAH1 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SIAH1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SIAH1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

LUAD, HNSC, and PDAC are the cancer types where SIAH1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.487	1.000	.002	40	view →
HNSC	DFS	Tertile	All	0.216	1.000	.021	26	view →
PDAC	DFS	Quartile	All	0.437	0.213	.030	4	view →
LSCC	OS	Median	II,III,IV	0.846	0.617	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SIAH1 tumor-vs-normal RNA expression · all SIAH1 data types