Across TCGA patient cohorts, SIAH1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,497 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIAH1-associated genes across cancer lineages are NKILA, POPDC3, and NIBAN1. Each is linked with SIAH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIAH1-to-partner and partner-to-SIAH1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIAH1→partner) and Y-score (partner→SIAH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NKILA →	+0.760	+0.303	<.001	<.001	3	3
HNSC	POPDC3 →	+0.992	+0.287	.002	.004	3	2
LSCC	NIBAN1 →	-0.625	-0.298	<.001	<.001	3	2
HNSC	CYP2C9 →	-0.708	-0.272	.009	.004	3	2
HNSC	PPARGC1B →	-0.517	-0.260	.004	.009	3	2
HNSC	ZNF296 →	-0.566	-0.350	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,497 associations by consensus.

Exploration

SIAH1 survival (RNA) · tumor vs normal (RNA) · all SIAH1 data types