Across TCGA patient cohorts, SIAH1 mutation is significantly associated with the RNA expression of many other genes, with 1,820 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIAH1-associated genes across cancer lineages are RNU2-48P, RNU6-468P, and FABP12. Each is linked with SIAH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIAH1-to-partner and partner-to-SIAH1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIAH1→partner) and Y-score (partner→SIAH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU2-48P →	+0.297	+7.164	<.001	<.001	3	2
LIHC	RNU6-468P →	+0.324	+5.008	<.001	.004	3	2
UCEC	FABP12 →	+0.125	+1.727	.001	.006	3	2
UCEC	RNU6-130P →	+0.500	+1.867	<.001	.002	3	2
CESC	NEUROD6 →	+0.025	+5.812	<.001	.003	3	1
CESC	RNU6-562P →	+0.455	+5.418	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,820 associations by consensus.

Exploration

SIAH1 survival (RNA) · tumor vs normal (RNA) · all SIAH1 data types