Across TCGA patient cohorts, SIAH1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIAH1-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and ERK2. Each is linked with SIAH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIAH1-to-partner and partner-to-SIAH1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIAH1→partner) and Y-score (partner→SIAH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.099	-2.295	.014	.033	3	1
UCEC	eIF4E →	+0.172	+2.584	.042	.010	3	1
UCEC	ERK2 →	+0.161	+3.321	.037	.010	3	1
UCEC	FOXO3a →	-0.096	-2.292	.018	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.189	-3.321	.005	.010	3	1
UCEC	MEK1 →	+0.369	+2.584	.012	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

SIAH1 survival (RNA) · tumor vs normal (RNA) · all SIAH1 data types