Across TCGA cell cohorts, SIAH1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SIAH1-associated genes across cancer lineages are C10orf53, HELT, and LEUTX. Each is linked with SIAH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIAH1-to-partner and partner-to-SIAH1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIAH1→partner) and Y-score (partner→SIAH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C10orf53 →	+0.024	+5.217	<.001	<.001	3	1
CNS	HELT →	+0.027	+4.321	<.001	.009	3	1
CNS	LEUTX →	+0.168	+4.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

SIAH1 survival (RNA) · tumor vs normal (RNA) · all SIAH1 data types