SIAE

Across TCGA pan-cancer cohorts, SIAE mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SIAE data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SIAE mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SIAE expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where SIAE mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	II,III,IV	0.420	0.863	.004	11	view →
LUAD	DFS	Median	All	0.898	1.000	.021	6	view →
HNSC	DFS	Tertile	II,III,IV	0.891	0.978	.017	4	view →
PDAC	OS	Median	II,III,IV	0.921	0.743	.030	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SIAE–CCRCC (DFS)

Open the CCRCC breakdown →