Across TCGA pan-cancer cohorts, SHTN1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SHTN1 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SHTN1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SHTN1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, PDAC, and CCRCC are the cancer types where SHTN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	1.000	0.424	.003	24	view →
PDAC	OS	Tertile	All	0.916	0.782	.020	21	view →
CCRCC	DFS	Median	III,IV	0.528	0.870	.010	10	view →
LUAD	DFS	Median	All	0.848	0.946	.020	9	view →
LSCC	DFS	Tertile	II,III,IV	0.982	0.832	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SHTN1 tumor-vs-normal RNA expression · all SHTN1 data types