Across TCGA patient cohorts, SHTN1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,940 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SHTN1-associated genes across cancer lineages are ANXA7, DCLRE1A, and GPR161. Each is linked with SHTN1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SHTN1-to-partner and partner-to-SHTN1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHTN1→partner) and Y-score (partner→SHTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ANXA7 →	+0.483	+0.433	.001	.001	3	6
LSCC	DCLRE1A →	+0.530	+0.392	.002	<.001	3	6
UCEC	GPR161 →	-0.880	-0.493	<.001	.002	3	5
UCEC	SCHIP1 →	-0.658	-0.550	<.001	<.001	3	5
UCEC	GJC1 →	-0.794	-0.339	.002	.005	3	5
BRCA	TMEM158 →	-1.105	-0.278	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,940 associations by consensus.

Exploration

SHTN1 survival (RNA) · tumor vs normal (RNA) · all SHTN1 data types