Across TCGA patient cohorts, SHTN1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHTN1-associated genes across cancer lineages are ATM, PTEN, and ASNS. Each is linked with SHTN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SHTN1-to-partner and partner-to-SHTN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHTN1→partner) and Y-score (partner→SHTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.498	-1.893	<.001	.014	3	3
UCEC	PTEN →	-0.281	-2.321	.031	.033	3	2
UCEC	ASNS →	+0.346	+1.415	.003	.043	3	2
UCEC	4E-BP1_pT37_T46 →	-0.299	-2.308	.015	.005	3	2
UCEC	BRD4 →	+0.240	+2.222	.008	.009	3	2
UCEC	14-3-3_beta →	-0.084	-2.088	.011	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

SHTN1 survival (RNA) · tumor vs normal (RNA) · all SHTN1 data types