Across TCGA cell cohorts, SHTN1 mutation is significantly associated with the RNA expression of many other genes, with 128 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHTN1-associated genes across cancer lineages are SELE, AKAP10, and NDUFC1. Each is linked with SHTN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHTN1-to-partner and partner-to-SHTN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHTN1→partner) and Y-score (partner→SHTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SELE →	+0.011	+4.705	<.001	.003	3	1
LARGE_INTESTINE	AKAP10 →	+0.621	+3.364	.009	.002	3	1
LARGE_INTESTINE	NDUFC1 →	+0.705	+3.364	.001	.002	3	1
LARGE_INTESTINE	MAGEB4 →	+0.009	+3.000	<.001	.003	3	1
LARGE_INTESTINE	DNAJB9 →	+0.553	+3.364	.006	.002	3	1
LARGE_INTESTINE	NFATC1 →	+1.044	+3.364	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 128 associations by consensus.

Exploration

SHTN1 survival (RNA) · tumor vs normal (RNA) · all SHTN1 data types