SHROOM3

Across TCGA pan-cancer cohorts, SHROOM3 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated SHROOM3 data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SHROOM3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SHROOM3 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

ACC, BLCA, and UCEC are the cancer types where SHROOM3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.102	0.674	<.001	45	view →
BLCA	DFS	Median	III,IV	1.000	0.551	.005	36	view →
UCEC	DFS	Median	All	0.830	0.624	.005	28	view →
HNSC	DFS	Median	All	0.274	0.609	<.001	20	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
LUSC	OS	Median	All	0.427	0.683	.005	13	view →
PCPG	OS	Median	All	0.078	0.955	<.001	12	view →
DLBC	OS	Median	All	0.054	0.842	<.001	12	view →
ESCA	DFS	Median	III,IV	0.080	0.442	<.001	6	view →
LGG	DFS	Median	All	0.110	0.826	<.001	3	view →
SCLC	OS	Median	II,III,IV	0.152	0.777	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

SHROOM3–ACC (DFS)

Open the ACC breakdown →