SHROOM3

Across TCGA patient cohorts, SHROOM3 mutation is significantly associated with the RNA expression of many other genes, with 3,862 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHROOM3-associated genes across cancer lineages are H2AZ1, SAAL1, and MSANTD3. Each is linked with SHROOM3 in more than 3 cancer types. Because this analysis shows association rather than direction, both SHROOM3-to-partner and partner-to-SHROOM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2AZ1 grouped by SHROOM3-low versus SHROOM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHROOM3→partner) and Y-score (partner→SHROOM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	H2AZ1 →	+0.421	+1.797	.002	<.001	3	4
UCEC	SAAL1 →	+0.360	+2.513	.001	<.001	3	4
UCEC	MSANTD3 →	+0.448	+1.595	<.001	<.001	3	4
UCEC	GRPEL1 →	+0.325	+2.662	<.001	<.001	3	4
UCEC	C4orf46 →	+0.524	+2.353	<.001	<.001	3	4
COAD	RPL4P6 →	+0.406	+3.297	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,862 associations by consensus.

H2AZ1 by SHROOM3 expression — UCEC

Explore this box plot interactively →