SHROOM3

Across TCGA patient cohorts, SHROOM3 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHROOM3-associated genes across cancer lineages are eEF2, Bid, and Caspase-7-cleavedD198. Each is linked with SHROOM3 in more than 4 cancer types. Because this analysis shows association rather than direction, both SHROOM3-to-partner and partner-to-SHROOM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by SHROOM3-low versus SHROOM3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHROOM3→partner) and Y-score (partner→SHROOM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eEF2 →	+0.436	+3.178	.002	.010	3	5
LUSC	Bid →	+0.158	+3.000	<.001	.035	3	3
UCEC	Caspase-7-cleavedD198 →	+0.524	+1.945	.003	.002	3	3
BLCA	14-3-3_zeta →	+0.287	+3.000	.002	.034	3	2
COAD	GAPDH →	+0.916	+3.178	<.001	.010	1	4
COAD	Chk1 →	+0.289	+3.178	.008	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

eEF2 by SHROOM3 expression — COAD

Explore this box plot interactively →