SHROOM2

Across TCGA patient cohorts, SHROOM2 mutation is significantly associated with the RNA expression of many other genes, with 4,982 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHROOM2-associated genes across cancer lineages are H3P16, NUDC, and UBE2S. Each is linked with SHROOM2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SHROOM2-to-partner and partner-to-SHROOM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H3P16 grouped by SHROOM2-low versus SHROOM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHROOM2→partner) and Y-score (partner→SHROOM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	H3P16 →	+0.719	+1.271	<.001	.005	3	4
SKCM	NUDC →	+0.368	+1.781	<.001	.004	3	4
UCEC	UBE2S →	+0.589	+2.080	<.001	<.001	3	4
LIHC	RN7SL332P →	+0.211	+5.355	<.001	.005	3	4
UCEC	ATP2A1-AS1 →	+0.583	+1.698	<.001	<.001	3	4
SKCM	LBX2 →	+0.752	+2.465	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,982 associations by consensus.

H3P16 by SHROOM2 expression — UCEC

Explore this box plot interactively →