SHROOM2

Across TCGA patient cohorts, SHROOM2 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHROOM2-associated genes across cancer lineages are Annexin_VII, FoxM1, and PCNA. Each is linked with SHROOM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SHROOM2-to-partner and partner-to-SHROOM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin_VII grouped by SHROOM2-low versus SHROOM2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHROOM2→partner) and Y-score (partner→SHROOM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	Annexin_VII →	-0.176	-3.169	.037	.020	3	3
UCEC	FoxM1 →	+0.149	+1.211	.021	.016	3	3
COAD	PCNA →	+0.235	+2.095	.005	.003	3	3
UCEC	Annexin-1 →	+0.472	+1.657	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+0.875	+2.016	.001	.015	3	3
SKCM	MIG-6 →	+0.141	+2.195	.041	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Annexin_VII by SHROOM2 expression — BRCA

Explore this box plot interactively →