SHROOM2

Across TCGA cell cohorts, SHROOM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,660 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SHROOM2-associated GO terms across cancer lineages are Pigment metabolic process involved in pigmentation, Release of sequestered calcium ion into cytosol, and Epithelial cell-cell adhesion. Each is linked with SHROOM2 in more than 10 cancer types. Because this analysis shows association rather than direction, both SHROOM2-to-partner and partner-to-SHROOM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pigment metabolic process involved in pigmentation grouped by SHROOM2-low versus SHROOM2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHROOM2→partner) and Y-score (partner→SHROOM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Pigment metabolic process involved in pigmentation →	-0.308	-1.899	<.001	<.001	3	11
URINARY_TRACT	Release of sequestered calcium ion into cytosol →	-0.085	-1.777	<.001	<.001	3	10
KIDNEY	Epithelial cell-cell adhesion →	+0.178	+0.882	.003	.009	3	8
LUNG_NSCLC_LUSC	Cytoplasmic microtubule organization →	+0.078	+1.575	.001	.005	3	7
PANCREAS	Regulation of myoblast fusion →	+0.089	+1.172	.004	.002	3	7
SOFT_TISSUE	Endosomal transport →	+0.041	+1.004	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,660 associations by consensus.

Pigment metabolic process involved in pigmentation by SHROOM2 expression — URINARY_TRACT

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