SHROOM2

Across TCGA cell cohorts, SHROOM2 mutation is significantly associated with the RNA expression of many other genes, with 604 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHROOM2-associated genes across cancer lineages are WFDC6, IFT27, and PLTP. Each is linked with SHROOM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHROOM2-to-partner and partner-to-SHROOM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC6 grouped by SHROOM2-low versus SHROOM2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHROOM2→partner) and Y-score (partner→SHROOM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	WFDC6 →	+0.050	+4.887	<.001	.009	3	2
LARGE_INTESTINE	IFT27 →	+0.834	+2.936	<.001	<.001	3	2
LARGE_INTESTINE	PLTP →	-1.712	-3.169	.004	.006	3	2
LARGE_INTESTINE	ACBD5 →	+0.729	+2.158	.001	.004	3	2
BLOOD_Leukemia	HDAC1 →	+0.489	+2.204	.003	.005	3	2
LARGE_INTESTINE	PAIP2B →	+0.783	+3.949	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 604 associations by consensus.

WFDC6 by SHROOM2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →