SHROOM1

Across TCGA pan-cancer cohorts, SHROOM1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SHROOM1 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SHROOM1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SHROOM1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LSCC, CCRCC, and LUAD are the cancer types where SHROOM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.540	0.799	.011	10	view →
CCRCC	OS	Median	IV	1.000	0.189	.036	4	view →
LUAD	DFS	Tertile	All	0.533	0.767	.029	4	view →
PDAC	DFS	Quartile	III,IV	0.200	0.738	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SHROOM1–LSCC (DFS)

Open the LSCC breakdown →