SHROOM1

Across TCGA patient cohorts, SHROOM1 protein abundance is significantly associated with the RNA expression of many other genes, with 9,151 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SHROOM1-associated genes across cancer lineages are SBK1, MITF, and PLAT. Each is linked with SHROOM1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SHROOM1-to-partner and partner-to-SHROOM1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHROOM1 versus SBK1 in GBM, with a Pearson correlation of -0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHROOM1→partner) and Y-score (partner→SHROOM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SBK1 →	-1.077	-0.348	<.001	<.001	3	4
BRCA	MITF →	+0.712	+0.582	<.001	<.001	3	4
BRCA	PLAT →	+1.735	+0.638	<.001	<.001	3	3
BRCA	NCAM2 →	+0.927	+0.529	.003	<.001	3	3
UCEC	IFITM2 →	+0.709	+0.286	.001	<.001	3	3
LSCC	HIRA →	-0.333	-0.327	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,151 associations by consensus.

SHROOM1 vs SBK1 — GBM

Explore this scatter interactively →