SHROOM1

Across TCGA patient cohorts, SHROOM1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHROOM1-associated genes across cancer lineages are Annexin-1, Caspase-8, and MEK1. Each is linked with SHROOM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHROOM1-to-partner and partner-to-SHROOM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by SHROOM1-low versus SHROOM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHROOM1→partner) and Y-score (partner→SHROOM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.918	+2.827	.001	.035	3	2
UCEC	Caspase-8 →	-0.281	-2.973	.042	.035	3	1
UCEC	MEK1 →	+0.399	+3.169	.047	.020	2	1
SKCM	Bad_pS112 →	+0.292	+3.459	.001	.005	1	1
UCEC	Notch1 →	+0.249	+3.169	.001	.020	1	1
UCEC	p62 Lck ligand →	+0.461	+3.169	.009	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Annexin-1 by SHROOM1 expression — UCEC

Explore this box plot interactively →