SHROOM1

Across TCGA cell cohorts, SHROOM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,241 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SHROOM1-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and N-glycan processing. Each is linked with SHROOM1 in more than 10 cancer types. Because this analysis shows association rather than direction, both SHROOM1-to-partner and partner-to-SHROOM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by SHROOM1-low versus SHROOM1-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHROOM1→partner) and Y-score (partner→SHROOM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Negative regulation of myoblast fusion →	+0.105	+1.465	<.001	<.001	3	10
BLOOD_Lymphoma	Negative regulation of syncytium formation by plasma membrane fusion →	+0.102	+1.465	<.001	<.001	3	10
KIDNEY	N-glycan processing →	+0.116	+1.421	.004	.004	3	10
URINARY_TRACT	Regulation of intracellular transport →	+0.052	+1.395	.001	.004	2	11
BONE	Actomyosin contractile ring organization →	+0.200	+2.021	<.001	.001	3	10
LARGE_INTESTINE	Regulation of response to type II interferon →	+0.178	+1.482	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,241 associations by consensus.

Negative regulation of myoblast fusion by SHROOM1 expression — BLOOD_Lymphoma

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