SHROOM1

Across TCGA cell cohorts, SHROOM1 mutation is significantly associated with the RNA expression of many other genes, with 451 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHROOM1-associated genes across cancer lineages are OR10K1, DAZ2, and CT47A6. Each is linked with SHROOM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHROOM1-to-partner and partner-to-SHROOM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10K1 grouped by SHROOM1-low versus SHROOM1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHROOM1→partner) and Y-score (partner→SHROOM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10K1 →	+0.492	+4.234	<.001	.003	3	2
OVARY	DAZ2 →	+0.106	+5.807	<.001	.001	3	2
OVARY	CT47A6 →	+0.030	+5.807	<.001	.001	3	2
URINARY_TRACT	OR2A2 →	+0.046	+5.087	<.001	.004	3	1
PANCREAS	OR2T35 →	+0.012	+4.029	<.001	.007	3	1
PANCREAS	KRTAP2-2 →	+0.050	+4.029	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 451 associations by consensus.

OR10K1 by SHROOM1 expression — BLOOD_Leukemia

Explore this box plot interactively →