SHOC2

Across TCGA patient cohorts, SHOC2 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,434 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SHOC2-associated proteins across cancer lineages are NHLRC2, SLK, and PTCD3. Each is linked with SHOC2 in more than 6 cancer types. Because this analysis shows association rather than direction, both SHOC2-to-partner and partner-to-SHOC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHOC2 versus NHLRC2 in UCEC, with a Pearson correlation of 0.27.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SHOC2→partner) and Y-score (partner→SHOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NHLRC2 →	+0.347	+0.500	<.001	<.001	3	7
UCEC	SLK →	+0.386	+0.396	<.001	<.001	3	6
BRCA	PTCD3 →	-0.251	-0.673	<.001	<.001	3	5
BRCA	ARL3 →	+0.335	+0.477	<.001	<.001	3	4
GBM	BAG3 →	+0.496	+0.285	<.001	<.001	3	4
BRCA	LRPPRC →	-0.370	-0.509	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,434 associations by consensus.

SHOC2 vs NHLRC2 — UCEC

Explore this scatter interactively →