SHOC2

Across TCGA patient cohorts, SHOC2 protein abundance is significantly associated with the RNA expression of many other genes, with 7,836 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SHOC2-associated genes across cancer lineages are INPP5F, VPS37D, and ANXA7. Each is linked with SHOC2 in more than 4 cancer types. Because this analysis shows association rather than direction, both SHOC2-to-partner and partner-to-SHOC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHOC2 versus INPP5F in GBM, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHOC2→partner) and Y-score (partner→SHOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	INPP5F →	+0.724	+0.249	<.001	<.001	3	5
HNSC	VPS37D →	-0.645	-0.160	.002	.005	3	4
UCEC	ANXA7 →	+0.408	+0.191	.001	<.001	3	4
BRCA	WBP1L →	+0.554	+0.223	<.001	.001	3	4
UCEC	TRIM8 →	+0.624	+0.290	<.001	<.001	3	4
UCEC	C5orf34 →	-0.581	-0.228	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,836 associations by consensus.

SHOC2 vs INPP5F — GBM

Explore this scatter interactively →