SHOC2

Across TCGA patient cohorts, SHOC2 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHOC2-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and FASN. Each is linked with SHOC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHOC2-to-partner and partner-to-SHOC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by SHOC2-low versus SHOC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHOC2→partner) and Y-score (partner→SHOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.081	-1.973	.020	.029	3	2
UCEC	EGFR_pY1068 →	-0.224	-2.115	.009	.016	3	2
UCEC	FASN →	+0.302	+1.906	.027	.015	3	2
UCEC	MEK1 →	+0.382	+1.736	.002	.007	3	2
UCEC	PCNA →	+0.307	+2.938	<.001	<.001	3	2
UCEC	PDCD4 →	-0.577	-2.405	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

14-3-3_beta by SHOC2 expression — UCEC

Explore this box plot interactively →