SHOC2

Across TCGA cell cohorts, SHOC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,152 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SHOC2-associated GO terms across cancer lineages are Phosphatidylinositol metabolic process, Negative regulation of keratinocyte differentiation, and Positive regulation of Ras protein signal transduction. Each is linked with SHOC2 in more than 12 cancer types. Because this analysis shows association rather than direction, both SHOC2-to-partner and partner-to-SHOC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Phosphatidylinositol metabolic process grouped by SHOC2-low versus SHOC2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHOC2→partner) and Y-score (partner→SHOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Phosphatidylinositol metabolic process →	+0.057	+1.103	<.001	<.001	3	13
BONE	Negative regulation of keratinocyte differentiation →	+0.161	+0.734	.002	.003	3	12
PANCREAS	Positive regulation of Ras protein signal transduction →	+0.177	+0.807	<.001	<.001	3	12
LIVER	Phosphatidylinositol dephosphorylation →	+0.075	+0.695	<.001	<.001	3	12
OVARY	Negative regulation of calcium ion import across plasma membrane →	+0.106	+0.624	.002	.003	2	13
BREAST	Inositol phosphate metabolic process →	+0.055	+0.839	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,152 associations by consensus.

Phosphatidylinositol metabolic process by SHOC2 expression — LIVER

Explore this box plot interactively →