SHOC1

Across TCGA pan-cancer cohorts, SHOC1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SHOC1 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SHOC1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SHOC1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

HNSC, UCEC, and LUAD are the cancer types where SHOC1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.177	0.699	<.001	24	view →
UCEC	DFS	Median	II,III,IV	0.869	0.433	.033	16	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	12	view →
COAD	OS	Median	II,III,IV	0.597	0.858	.004	10	view →
PRAD	DFS	Median	All	0.200	0.775	.013	6	view →
LUSC	DFS	Median	All	1.000	0.654	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SHOC1–HNSC (DFS)

Open the HNSC breakdown →