SHOC1

Across TCGA patient cohorts, SHOC1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,732 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SHOC1-associated proteins across cancer lineages are KIF21A_S1212, C2, and TMEM245. Each is linked with SHOC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SHOC1-to-partner and partner-to-SHOC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHOC1 versus KIF21A_S1212 in BRCA, with a Pearson correlation of -0.19.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SHOC1→partner) and Y-score (partner→SHOC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KIF21A_S1212 →	-0.447	-0.224	<.001	.007	3	4
OV	C2 →	+0.476	+0.234	<.001	.007	3	4
UCEC	TMEM245 →	+0.765	+1.260	<.001	<.001	3	4
BRCA	POLR3A →	-0.153	-0.313	.002	<.001	3	3
UCEC	PTPN21_S577 →	+0.443	+1.056	.005	.002	2	4
CCRCC	RAI14 →	+0.290	+0.610	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,732 associations by consensus.

SHOC1 vs KIF21A_S1212 — BRCA

Explore this scatter interactively →