SHOC1

Across TCGA patient cohorts, SHOC1 mutation is significantly associated with the RNA expression of many other genes, with 4,909 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHOC1-associated genes across cancer lineages are RPL17P13, PANK4, and RAC3. Each is linked with SHOC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SHOC1-to-partner and partner-to-SHOC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL17P13 grouped by SHOC1-low versus SHOC1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHOC1→partner) and Y-score (partner→SHOC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPL17P13 →	+0.083	+4.063	<.001	.004	3	3
UCEC	PANK4 →	+0.393	+1.747	<.001	<.001	3	3
SKCM	RAC3 →	+0.892	+2.594	.008	.006	3	3
BLCA	RN7SKP283 →	+0.059	+4.040	.001	.007	3	2
BLCA	GATD3B →	+0.539	+3.249	.004	.009	3	2
UCEC	CCL5 →	+0.923	+1.758	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,909 associations by consensus.

RPL17P13 by SHOC1 expression — HNSC

Explore this box plot interactively →