SHOC1

Across TCGA cell cohorts, SHOC1 mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible SHOC1-associated genes across cancer lineages are ELOA3DP, DEFB108B, and OR12D3. Each is linked with SHOC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHOC1-to-partner and partner-to-SHOC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOA3DP grouped by SHOC1-low versus SHOC1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHOC1→partner) and Y-score (partner→SHOC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ELOA3DP →	+0.100	+4.209	<.001	.006	3	2
STOMACH	DEFB108B →	+0.040	+3.662	<.001	.001	3	1
UPPER_AERODIGESTIVE_TRACT	OR12D3 →	+0.020	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	OR7G1 →	+0.087	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	OR4K2 →	+0.122	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	TAS1R2 →	+0.034	+4.510	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

ELOA3DP by SHOC1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →