SHMT1

Across TCGA pan-cancer cohorts, SHMT1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SHMT1 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SHMT1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SHMT1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, GBM, and CCRCC are the cancer types where SHMT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	III,IV	0.972	0.422	<.001	26	view →
GBM	OS	Tertile	All	0.711	0.911	.007	14	view →
CCRCC	OS	Quartile	All	1.000	0.855	.013	13	view →
HNSC	DFS	Median	II,III,IV	0.554	0.783	.008	12	view →
LUAD	DFS	Quartile	II,III,IV	1.000	0.378	.001	9	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SHMT1–LSCC (DFS)

Open the LSCC breakdown →