SHMT1

Across TCGA patient cohorts, SHMT1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,722 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SHMT1-associated genes across cancer lineages are PRPSAP2, ALDH3A2, and TTC19. Each is linked with SHMT1 in more than 7 cancer types. Because this analysis shows association rather than direction, both SHMT1-to-partner and partner-to-SHMT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHMT1 versus PRPSAP2 in UCEC, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHMT1→partner) and Y-score (partner→SHMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRPSAP2 →	+0.771	+0.610	<.001	<.001	3	8
UCEC	ALDH3A2 →	+0.929	+0.427	<.001	.001	3	7
BRCA	TTC19 →	+0.488	+0.372	<.001	<.001	3	6
HNSC	EVPLL →	+0.415	+0.291	.002	.002	3	6
UCEC	ZSWIM7 →	+0.646	+0.392	<.001	<.001	3	6
LSCC	ALKBH5 →	+0.403	+0.309	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,722 associations by consensus.

SHMT1 vs PRPSAP2 — UCEC

Explore this scatter interactively →