SHMT1

Across TCGA patient cohorts, SHMT1 mutation is significantly associated with the RNA expression of many other genes, with 1,499 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHMT1-associated genes across cancer lineages are OR4A45P, RPSAP68, and TRAJ18. Each is linked with SHMT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHMT1-to-partner and partner-to-SHMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4A45P grouped by SHMT1-low versus SHMT1-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHMT1→partner) and Y-score (partner→SHMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	OR4A45P →	+0.189	+7.977	<.001	.007	3	2
LGG	RPSAP68 →	+0.104	+7.977	<.001	.007	3	2
COAD	TRAJ18 →	+0.816	+3.364	.001	.003	3	2
COAD	TRAJ5 →	+1.376	+3.364	<.001	.003	3	2
COAD	MIR4316 →	+0.546	+3.868	<.001	.003	3	2
CESC	MTND6P17 →	+0.076	+8.174	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,499 associations by consensus.

OR4A45P by SHMT1 expression — LGG

Explore this box plot interactively →