SHMT1

Across TCGA patient cohorts, SHMT1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHMT1-associated genes across cancer lineages are MSH6, Stathmin, and VHL. Each is linked with SHMT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHMT1-to-partner and partner-to-SHMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by SHMT1-low versus SHMT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHMT1→partner) and Y-score (partner→SHMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.469	-2.584	<.001	.010	3	2
UCEC	Stathmin →	+0.130	+1.584	.016	.036	3	2
UCEC	VHL →	-0.831	-1.700	.001	.042	3	2
UCEC	Bax →	+0.189	+1.584	.044	.036	3	2
UCEC	Caspase-7-cleavedD198 →	+0.899	+2.242	<.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.290	-2.502	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

MSH6 by SHMT1 expression — UCEC

Explore this box plot interactively →